The structure of the Helicobacter pylori ferric uptake regulator Fur reveals three functional metal binding sites.
作者： Cyril Dian , Sylvia Vitale , Gordon A. Leonard , Christelle Bahlawane , Caroline Fauquant
DOI: 10.1111/J.1365-2958.2010.07517.X
关键词:
摘要: … In Helicobacter pylori, HpFur is involved in acid response and is important for gastric colonization in model animals. Here we present the crystal structure … , the crystal structure of HpFur …
rcsb.org
archives-ouvertes.fr参考文章(65)
W. L. Delano, The PyMOL Molecular Graphics System DeLano Scientific. ,(2002)
Anjali Nandal, Cerys C. O. Huggins, Mark R. Woodhall, Jonathan McHugh, Francisco Rodríguez-Quiñones, Michael A. Quail, John R. Guest, Simon C. Andrews, Induction of the ferritin gene (ftnA) of Escherichia coli by Fe2+–Fur is mediated by reversal of H-NS silencing and is RyhB independent Molecular Microbiology. ,vol. 75, pp. 637- 657 ,(2010) , 10.1111/J.1365-2958.2009.06977.X
Anastassis Perrakis, Richard Morris, Victor S. Lamzin, Automated protein model building combined with iterative structure refinement. Nature Structural & Molecular Biology. ,vol. 6, pp. 458- 463 ,(1999) , 10.1038/8263
Isabel Delany, Gunther Spohn, Ana-Beatriz F. Pacheco, Raffaele Ieva, Cristina Alaimo, Rino Rappuoli, Vincenzo Scarlato, Autoregulation of Helicobacter pylori Fur revealed by functional analysis of the iron-binding site. Molecular Microbiology. ,vol. 46, pp. 1107- 1122 ,(2002) , 10.1046/J.1365-2958.2002.03227.X
Isabel Delany, Gunther Spohn, Rino Rappuoli, Vincenzo Scarlato, The Fur repressor controls transcription of iron-activated and -repressed genes in Helicobacter pylori Molecular Microbiology. ,vol. 42, pp. 1297- 1309 ,(2002) , 10.1046/J.1365-2958.2001.02696.X
Stéphanie Bury-Moné, Jean-Michel Thiberge, Monica Contreras, Aboubakar Maitournam, Agnès Labigne, Hilde De Reuse, Responsiveness to acidity via metal ion regulators mediates virulence in the gastric pathogen Helicobacter pylori. Molecular Microbiology. ,vol. 53, pp. 623- 638 ,(2004) , 10.1111/J.1365-2958.2004.04137.X
Alberto Danielli, Vincenzo Scarlato, Regulatory circuits in Helicobacter pylori : network motifs and regulators involved in metal-dependent responses. Fems Microbiology Reviews. ,vol. 34, pp. 738- 752 ,(2010) , 10.1111/J.1574-6976.2010.00233.X
Ellen Wang Althaus, Caryn E. Outten, Katherine E. Olson, Hua Cao, Thomas V. O'Halloran, The ferric uptake regulation (Fur) repressor is a zinc metalloprotein. Biochemistry. ,vol. 38, pp. 6559- 6569 ,(1999) , 10.1021/BI982788S
Thomas R. Schneider, George M. Sheldrick, Substructure solution with SHELXD. Acta Crystallographica Section D-biological Crystallography. ,vol. 58, pp. 1772- 1779 ,(2002) , 10.1107/S0907444902011678
Anne Bagg, J. B. Neilands, Ferric uptake regulation protein acts as a repressor, employing iron (II) as a cofactor to bind the operator of an iron transport operon in Escherichia coli. Biochemistry. ,vol. 26, pp. 5471- 5477 ,(1987) , 10.1021/BI00391A039