Elevated corticosterone levels. A possible cause of reduced axon sprouting in aged animals.

摘要: Measurements of serum corticosterone taken at three times in the diurnal cycle (08.00, 18.00, and 23.30 h) showed that aged male Sprague-Dawley rats have higher nonstressed circulating levels two time points measured. To determine if such elevated steroids were sufficient to interfere with lesion-induced sprouting, peak 18.00 h either or young adult animals was maintained adrenalectomized by use subcutaneous pellets. The normal animal resulted mild suppression adrenergic sprouting response seen hippocampus following transection fimbria-fornix. Young senescent had marked sprouting. glucocorticoids reached are retard may therefore synaptic turnover brain damage.