[Corrigendum] Effect of type 2 diabetes mellitus caveolin‑3 K15N mutation on glycometabolism
作者： Yiyuan Huang , Yufeng Deng , Lina Shang , Lihui Yang , Juanjuan Huang
关键词:
摘要: Caveolin-3 (CAV3) is a muscle-specific protein present within the muscle cell membrane that affects signaling pathways, including insulin pathway. A previous assessment of patients with newly developed type 2 diabetes (T2DM) demonstrated CAV3 gene mutations may lead to changes in secondary structure. severe P104L mutation has previously been indicated influence phosphorylation skeletal cells and result impaired glucose metabolism. In study, effect K15N transfection C2C12 was assessed. Transfection reduced expression total AKT2 proteins cells, translocation transporter 4 membrane, which resulted decreased uptake glycogen synthesis myocytes. conclusion, these results indicate cause insulin-stimulated metabolism myocytes, contribute development T2DM.
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