Epigenetic programming of differential gene expression in development and evolution

作者: Marilyn Monk

DOI: 10.1002/DVG.1020170303

关键词:

摘要: This review covers data on changing patterns of DNA methylation and the regulation gene expression in mouse embryonic development. Global demethylation occurs from eight-cell stage to blastocyst preimplantation embryos, global de novo begins at implantation. We have used X-chromosome inactivation female embryos as a model system study specific CpG sites X-linked Pgk-1 G6pd housekeeping genes imprinted regulatory Xist elucidate role initiation maintenance differential activity. Methylation very close time their inactivation, thus raising question whether could be causal well being involved its maintenance. A difference between sperm eggs promoter region gene, located centre, is correlated with preferential paternal X chromosome extra-embryonic tissues. Based our data, picture inheritance imprints speculation significance imprint development presented. On more general level, an hypothesis evolution by "adaptive epigenetic/genetic inheritance" considered. proposes modification germ line response change environment mutation site (e.g., methylated cytosine thymine). Epigenetic function shift buffer evolving against changes environment. If altered activity inactivity persist, modifications may become "fixed" mutations; alternatively, previously silenced networks might recruited into function, appearing if they are "acquired characteristics." An extension this "foreign acquisition sorting" (selection or silencing according use). "Kidnapping" sorting foreign way explain observation that increased complexity associated "junk" DNA. Adaptive challenges "central dogma" information unidirectional protein idea Darwinian random selection sole mechanisms evolution.

参考文章(53)
Holmquist Gp, Role of replication time in the control of tissue-specific gene expression. American Journal of Human Genetics. ,vol. 40, pp. 151- 173 ,(1987)
V. Monesi, R. Geremia, A. D'agostino, C. Boitani, Biochemistry of male germ cell differentiation in mammals: RNA synthesis in meiotic and postmeiotic cells. Current Topics in Developmental Biology. ,vol. 12, pp. 11- 36 ,(1978) , 10.1016/S0070-2153(08)60592-X
M. Brandeis, T. Kafri, M. Ariel, J.R. Chaillet, J. McCarrey, A. Razin, H. Cedar, The ontogeny of allele-specific methylation associated with imprinted genes in the mouse The EMBO Journal. ,vol. 12, pp. 3669- 3677 ,(1993) , 10.1002/J.1460-2075.1993.TB06041.X
J Singer-Sam, M Grant, J M LeBon, K Okuyama, V Chapman, M Monk, A D Riggs, Use of a HpaII-polymerase chain reaction assay to study DNA methylation in the Pgk-1 CpG island of mouse embryos at the time of X-chromosome inactivation. Molecular and Cellular Biology. ,vol. 10, pp. 4987- 4989 ,(1990) , 10.1128/MCB.10.9.4987
R. Stein, Y. Gruenbaum, Y. Pollack, A. Razin, H. Cedar, Clonal inheritance of the pattern of DNA methylation in mouse cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 79, pp. 61- 65 ,(1982) , 10.1073/PNAS.79.1.61
Neil Brockdorff, Alan Ashworth, Graham F. Kay, Penny Cooper, Sandy Smith, Veronica M. McCabe, Dominic P. Norris, Graeme D. Penny, Dipika Patel, Sohaila Rastan, Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome Nature. ,vol. 351, pp. 329- 331 ,(1991) , 10.1038/351329A0
Carolyn J. Brown, Andrea Ballabio, James L. Rupert, Ronald G. Lafreniere, Markus Grompe, Rossana Tonlorenzi, Huntington F. Willard, A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome Nature. ,vol. 349, pp. 38- 44 ,(1991) , 10.1038/349038A0
Dominic P. Norris, Dipika Patel, Graham F. Kay, Graeme D. Penny, Neil Brockdorff, Steven A. Sheardown, Sohaila Rastan, Evidence that random and imprinted Xist expression is controlled by preemptive methylation Cell. ,vol. 77, pp. 41- 51 ,(1994) , 10.1016/0092-8674(94)90233-X
Michael Wigler, Daniel Levy, Manuel Perucho, The somatic replication of DNA methylation Cell. ,vol. 24, pp. 33- 40 ,(1981) , 10.1016/0092-8674(81)90498-0
Michelle Hadchouel, Hend Farza, Dominique Simon, Pierre Tiollais, Christine Pourcel, Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation. Nature. ,vol. 329, pp. 454- 456 ,(1987) , 10.1038/329454A0