Treatment of Chronic Hepatitis C Virus Infection: A Clinical and Virological Perspective
作者： David R. Gretch , Stephen J. Polyak , Richard A. Willson , Robert L. Carithers
DOI: 10.1007/978-1-4757-9209-6_20
关键词:
摘要: Hepatitis C virus (HCV), the etiologic agent of chronic non-A, non-B hepatitis,is a 9.4 kb positive strand RNA classified within Flaviviridae family.1 The genome HCV encodes single precursor polyprotein 3011 amino acids, which is cleaved by host and viral proteases into series structural non-structural proteins as reviewed elsewhere (Figure 1). (reviewed in reference 2) Although gene products have not been definitively identified infected hosts, they successfully expressed via genetic engineering.3,4 (core envelope) are thought to circulate blood individuals virion components, while (NS2-NS5) function regulatory enzymes (e.g., protease, helicase, replicase) during intracellular phase life cycle.
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sci-hub.st 参考文章(116)
Longombardo G, Pasero G, Highfield P, Marzo E, Moretti A, Greco F, Bombardieri S, Palla P, Ferri C, Mazzoni A, Association between hepatitis C virus and mixed cryoglobulinemia [see comment]. Clinical and Experimental Rheumatology. ,vol. 9, pp. 621- ,(1991)
Hayashi H, Takikawa T, Yano M, Nishimura N, Sakamoto N, Isomura T, Improvement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C and excess hepatic iron. The American Journal of Gastroenterology. ,vol. 89, pp. 986- 988 ,(1994)
M Casato, B Lagana, G Antonelli, F Dianzani, L Bonomo, Long-term results of therapy with interferon-alpha for type II essential mixed cryoglobulinemia Blood. ,vol. 78, pp. 3142- 3147 ,(1991) , 10.1182/BLOOD.V78.12.3142.3142
Richard Willson, David R. Gretch, Richard J. Johnson, Hideaki Yamabe, Mark H. Wener, Lawrence Corey, Charles Alpers, Clinical, Immunological, and Virological Features of HCV-associated Membranoproliferative Glomerulonephritis Viral Hepatitis and Liver Disease. pp. 218- 221 ,(1994) , 10.1007/978-4-431-68255-4_55
Harvey J. Alter, Chronic Consequences of Non-A, Non-B Hepatitis Current Perspectives in Hepatology. pp. 83- 97 ,(1989) , 10.1007/978-1-4684-7041-3_8
C Ferri, E Marzo, G Longombardo, F Lombardini, L La Civita, R Vanacore, AM Liberati, R Gerli, F Greco, A Moretti, Interferon-alpha in mixed cryoglobulinemia patients: a randomized, crossover-controlled trial Blood. ,vol. 81, pp. 1132- 1136 ,(1993) , 10.1182/BLOOD.V81.5.1132.1132
Adrian M. Di Bisceglie, Constantine A. Axiotis, Jay H. Hoofnagle, Bruce R. Bacon, Measurements of iron status in patients with chronic hepatitis. Gastroenterology. ,vol. 102, pp. 2108- 2113 ,(1992) , 10.1016/0016-5085(92)90339-Z
A J Weiner, M M Thaler, K Crawford, K Ching, J Kansopon, D Y Chien, J E Hall, F Hu, M Houghton, A unique, predominant hepatitis C virus variant found in an infant born to a mother with multiple variants. Journal of Virology. ,vol. 67, pp. 4365- 4368 ,(1993) , 10.1128/JVI.67.7.4365-4368.1993
Pauline Jouët, Françoise Roudot-Thoraval, Daniel Dhumeaux, Jean-Michel Métreau, Comparative efficacy of interferon alfa in cirrhotic and noncirrhotic patients with non-A, non-B, C hepatitis Gastroenterology. ,vol. 106, pp. 686- 690 ,(1994) , 10.1016/0016-5085(94)90703-X
G.C. Sen, P Lengyel, The interferon system. A bird's eye view of its biochemistry. Journal of Biological Chemistry. ,vol. 267, pp. 5017- 5020 ,(1992) , 10.1016/S0021-9258(18)42719-6