PPARγ agonists: potential treatment for autism spectrum disorder by inhibiting the canonical WNT/β-catenin pathway

摘要: Autism spectrum disorder (ASD) is a neurodevelopmental that characterized by deficit in social interactions and communication with repetitive restrictive behavior. No curative treatments are available for ASD. Pharmacological do not address the core ASD behaviors, but target comorbid symptoms. Dysregulation of pathways associated clinical presentation ASD, canonical WNT/β-catenin pathway one major involved. The participates development central nervous system, its dysregulation involves developmental cognitive disorders. In numerous tissues, peroxisome proliferator-activated receptor gamma (PPARγ) act an opposed manner. increased while PPARγ seems to be decreased. agonists present beneficial effect treatment children through their anti-inflammatory role. Moreover, they induce inhibition several pathophysiological states. We focus this review on hypothesis interplay between potential role as