Segregation analysis of non-insulin-dependent diabetes mellitus in Pima Indians: evidence for a major-gene effect.

作者: W C Knowler , R L Hanson , D J Pettitt , R C Elston , P H Bennett

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摘要: Non-insulin-dependent diabetes mellitus (NIDDM) has a high prevalence in Pima Indians. The disorder is familial, but the extent to which genetic factors are involved its etiology largely unknown. Segregation analysis was used determine whether familial aggregation of NIDDM this population could reflect action single major gene. included 2,697 subjects from 653 nuclear families both parents and at least one offspring had been examined course longitudinal epidemiological study. REGTL program SAGE package fit models age onset transmitted parent under unified model for segregation analysis. Likelihood-ratio tests were test hypotheses related transmission. hypothesis no effect strongly rejected (P < .01), as that transmission .01). Mendelian not = .91). Similar results obtained when covariates obesity birth cohort added power transformation estimated. A strong with earlier later born cohorts observed findings consistent gene influences risk Indians by affecting onset. expression may depend on environmental have become more prevalent recent-birth cohorts.

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