Characterization of strut indentation during mechanical thrombectomy in acute ischemic stroke clot analogs.

摘要: Background Although it is common practice to wait for an ‘embedding time’ during mechanical thrombectomy (MT) allow strut integration of a stentriever device into occluding thromboembolic clot, there scarcity evidence demonstrating the value or optimal timing wide range thrombus compositions. This work characterizes behavior clot analogs varying fibrin and cellular compositions subject indentation forces embedding times representative those imparted by MT. The purpose this study quantify effect composition on embedding, examine precise nature at microstructural level. Method Clot with 0% (varying densities), 5%, 40%, 80% red blood cell (RBC) content were created using ovine blood. initial load application (loading phase) followed 5-min time (creep was analyzed tester under physiologically relevant conditions. mechanism examined micro-computed tomography (µCT) EmboTrap MT (Cerenovus, Galway, Ireland) deployed in each type. Microstructural characteristics identified scanning electron microscopy (SEM). Results Compressive stiffness measured loading phase shown be lowest RBC-rich clots, corresponding greatest maximum depth. Meanwhile, additional depth achieved simulated most pronounced fibrin-rich clots. SEM imaging variations mechanisms (fibrin stretching vs rupturing) which dependent fibrin:cellular content, while µCT analysis demonstrated predominantly formation surface undulations rather than penetration. Conclusions Disparities between attributed features induced cellular:fibrin content. Greater clots higher RBC but increased level rupture, suggesting propensity fragmentation. Additional improves integration, especially through majority occurring after 3 mins. incorporation primarily influenced design, regions open architecture.