NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling.
作者： Surojit Paul , Angus C. Nairn , Ping Wang , Paul J. Lombroso
DOI: 10.1038/NN989
关键词:
摘要: The intracellular mechanism(s) by which a cell determines the duration of extracellular signal–regulated kinase (ERK) activation is not well understood. We have investigated role STEP, striatal-enriched tyrosine phosphatase, in regulation ERK activity rat neurons. Glutamate-mediated NMDA receptors leads to rapid but transient phosphorylation cultured Here we show that led limited as its translocation nucleus and subsequent downstream nuclear signaling. In neurons, STEP phosphorylated inactive under basal conditions. NMDA-mediated influx Ca2+, increased Ca2+ from other sources, Ca2+-dependent phosphatase calcineurin dephosphorylation STEP. identified an important mechanism involved neurons highlights complex interplay between serine/threonine kinases phosphatases.
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