Molecular architecture of signal complexes regulating immune cell function.

摘要: Signals transmitted via multichain immunoreceptors control the development, differentiation and activation of hematopoetic cells. The cytoplasmic parts these receptors contain immunoreceptor tyrosine-based motifs (ITAMs) that upon phosphorylation by members Src tyrosine kinase family orchestrate a complex set signaling events involving phosphorylation, generation second messengers like DAG, IP3 Ca2+, effector molecules Ras MAPKs translocation transcription factors NFAT, API NF-kB. Spatial temporal organization is essential both to connect downstream cascades as well functional outcome immune activation. Throughout this process fine-tuning different signals are necessary for effective function in order avoid inappropriate or exaggerated autoimmunity. This includes modulating mechanisms threshold reset status after an response has been launched. One immunomodulating pathway cAMP-protein A-Csk scaffolded supramolecular residing lipid rafts with A kinase-anchoring protein (AKAP) ezrin, Csk-binding PAG linker between two, EBP50. Failure correct scaffolding loss spatiotemporal can potentially have severe consequences, leading failure clinical relevance complexes specifically organized proteins regulating activity specter genetic diseases linked components suggest protein-protein contact surfaces be potential targets drug intervention. It also interest note pathogens evolved strategies modulate signal integration, thereby rewiring way beneficial their survival. In addition demonstrating importance processes, adaptations elegant illustrations targeting assembly. chapter reviews some important focus on transduction through T-cell receptor (TCR).