Effects of Huangqin Decoction on ulcerative colitis by targeting estrogen receptor alpha and ameliorating endothelial dysfunction based on system pharmacology.

作者: Zi-ren Su , Yu-hong Liu , Xiao-qi Huang , Nan Xu , Hui-juan Luo

DOI: 10.1016/J.JEP.2021.113886

关键词:

摘要: … prediction, we used DSS-induced colitis mice to verify whether the … combination with tanshinone protect against DSS-induced ulcerative colitis through inhibiting TLR4/PI3K/AKT/mTOR …

参考文章(57)
Shwu-Huey Liu, Yung-Chi Cheng, None, Old formula, new Rx: the journey of PHY906 as cancer adjuvant therapy. Journal of Ethnopharmacology. ,vol. 140, pp. 614- 623 ,(2012) , 10.1016/J.JEP.2012.01.047
Juan Li, Wei Zhong, Weiwei Wang, Shaoping Hu, Jiahui Yuan, Bing Zhang, Tianhui Hu, Gang Song, Ginsenoside Metabolite Compound K Promotes Recovery of Dextran Sulfate Sodium-Induced Colitis and Inhibits Inflammatory Responses by Suppressing NF-κB Activation PLoS ONE. ,vol. 9, pp. e87810- ,(2014) , 10.1371/JOURNAL.PONE.0087810
S. Li, Z.Q. Zhang, L.J. Wu, X.G. Zhang, Y.Y. Wang, Y.D. Li, Understanding ZHENG in traditional Chinese medicine in the context of neuro-endocrine-immune network Iet Systems Biology. ,vol. 1, pp. 51- 60 ,(2007) , 10.1049/IET-SYB:20060032
Jun-ichi Furusawa, Megumi Funakoshi-Tago, Kenji Tago, Tadahiko Mashino, Hideo Inoue, Yoshiko Sonoda, Tadashi Kasahara, Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-κB p65 phosphorylation at serine 276 Cellular Signalling. ,vol. 21, pp. 778- 785 ,(2009) , 10.1016/J.CELLSIG.2009.01.021
Vicent Ribas, M. T. Audrey Nguyen, Darren C. Henstridge, Anh-Khoi Nguyen, Simon W. Beaven, Matthew J. Watt, Andrea L. Hevener, Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERα-deficient mice American Journal of Physiology-endocrinology and Metabolism. ,vol. 298, ,(2010) , 10.1152/AJPENDO.00504.2009
Yong Wang, Zhongyang Liu, Chun Li, Dong Li, Yulin Ouyang, Junda Yu, Shuzhen Guo, Fuchu He, Wei Wang, None, Drug target prediction based on the herbs components: the study on the multitargets pharmacological mechanism of qishenkeli acting on the coronary heart disease. Evidence-based Complementary and Alternative Medicine. ,vol. 2012, pp. 698531- 698531 ,(2012) , 10.1155/2012/698531
Francisco J Azuaje, Lu Zhang, Yvan Devaux, Daniel R Wagner, None, Drug-target network in myocardial infarction reveals multiple side effects of unrelated drugs Scientific Reports. ,vol. 1, pp. 52- 52 ,(2011) , 10.1038/SREP00052
Vivian W. Y. Wong, Daniel E. Stange, Mahalia E. Page, Simon Buczacki, Agnieszka Wabik, Satoshi Itami, Marc van de Wetering, Richard Poulsom, Nicholas A. Wright, Matthew W. B. Trotter, Fiona M. Watt, Doug J. Winton, Hans Clevers, Kim B. Jensen, Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling Nature Cell Biology. ,vol. 14, pp. 401- 408 ,(2012) , 10.1038/NCB2464
Stefan Wirtz, Clemens Neufert, Benno Weigmann, Markus F Neurath, Chemically induced mouse models of intestinal inflammation. Nature Protocols. ,vol. 2, pp. 541- 546 ,(2007) , 10.1038/NPROT.2007.41
Xiuxiu Li, Xue Xu, Jinan Wang, Hua Yu, Xia Wang, Hongjun Yang, Haiyu Xu, Shihuan Tang, Yan Li, Ling Yang, Luqi Huang, Yonghua Wang, Shengli Yang, A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment. PLOS ONE. ,vol. 7, ,(2012) , 10.1371/JOURNAL.PONE.0043918