Mechanisms for anaesthetic mediated changes in drug disposition
作者： Charles Stewart Reilly
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摘要: Anaesthesia may alter acutely the disposition of drugs in body. This be produced by changes hepatic blood flow, drug-metabolising enzyme activity or distribution drug The known effect anaesthesia on these determinants is described. control and factors affecting flow are discussed, as methods measuring it. Hepatic metabolising enzymes Their activity, mathematical models,methods assessment altering discussed.
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