SAM-T04: what is new in protein-structure prediction for CASP6.

摘要: The SAM-T04 method for predict- ing protein structures uses a single protocol across the entire range of targets, from comparative model- to new folds. This is similar SAM-T02 used in CASP5, but has improve- ments iterative search sequences finding and aligning templates, creating frag- ment libraries, generating conforma- tions, scoring conformations. auto- matic procedure made some improvements over simply selecting an alignment highest-scoring template, human intervention substantial automatic procedure. main by were adding constraints build (or retain) -sheets splitting multidomain proteins into separate domains. uniform was moderately successful target difficulty, somewhat less than other approaches CASP6 on compara- tive modeling targets. Proteins 2005;Suppl 7:135-142.