Glutamine:fructose-6-phosphate amidotransferase, its production and use
作者： Yasushi Shintani , Kazunori Nishi , Yukiko Hikichi
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摘要: This invention relates to glutamine:fructose-6-phosphate amidotransferase, or its partial peptide a salt thereof; DNA coding for the protein; recombinant vector; transformant; method producing pharmaceutical composition comprising protein, and an antibody against protein peptide. The thereof, are useful prophylactic therapeutic agent hypoglycemia. can be used in assay of thereof. thereof is as reagent screening candidate medical compounds.
google.com.tr 参考文章(20)
Rosalind Kornfeld, Studies on l-Glutamine d-Fructose 6-Phosphate Amidotransferase Journal of Biological Chemistry. ,vol. 242, pp. 3135- 3141 ,(1967) , 10.1016/S0021-9258(18)95943-0
G Watzele, W Tanner, Cloning of the glutamine:fructose-6-phosphate amidotransferase gene from yeast. Pheromonal regulation of its transcription. Journal of Biological Chemistry. ,vol. 264, pp. 8753- 8758 ,(1989) , 10.1016/S0021-9258(18)81857-9
G.L. McKnight, S.L. Mudri, S.L. Mathewes, R.R. Traxinger, S Marshall, P.O. Sheppard, P.J. O'Hara, Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase. Journal of Biological Chemistry. ,vol. 267, pp. 25208- 25212 ,(1992) , 10.1016/S0021-9258(19)74026-5
A. G. Nerlich, U. Sauer, V. Kolm-Litty, E. Wagner, M. Koch, E. D. Schleicher, Expression of Glutamine:Fructose-6-Phosphate Amidotransferase in Human Tissues: Evidence for High Variability and Distinct Regulation in Diabetes Diabetes. ,vol. 47, pp. 170- 178 ,(1998) , 10.2337/DIAB.47.2.170
Peter P. Sayeski, Jeffrey E. Kudlow, Glucose Metabolism to Glucosamine Is Necessary for Glucose Stimulation of Transforming Growth Factor-α Gene Transcription Journal of Biological Chemistry. ,vol. 271, pp. 15237- 15243 ,(1996) , 10.1074/JBC.271.25.15237
Jianxin Zhou, John L. Neidigh, Rafael Espinosa, Michelle M. LeBeau, Donald A. McClain, Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13. Human Genetics. ,vol. 96, pp. 99- 101 ,(1995) , 10.1007/BF00214194
D. A. McClain, E. D. Crook, Hexosamines and Insulin Resistance Diabetes. ,vol. 45, pp. 1003- 1009 ,(1996) , 10.2337/DIAB.45.8.1003
Peter P. Sayeski, Andrew J. Paterson, Jeffrey E. Kudlow, The murine glutamine:fructose-6-phosphate amidotransferase-encoding cDNA sequence. Gene. ,vol. 140, pp. 289- 290 ,(1994) , 10.1016/0378-1119(94)90560-6
Hui Chen, Brian L Ing, Katherine A Robinson, Amy C Feagin, Maria G Buse, Michael J Quon, Effects of overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT) and glucosamine treatment on translocation of GLUT4 in rat adipose cells Molecular and Cellular Endocrinology. ,vol. 135, pp. 67- 77 ,(1997) , 10.1016/S0303-7207(97)00191-3
Mahmood Vessal, W. Z. Hassid, Partial Purification and Properties of l-Glutamine d-Fructose 6-Phosphate Amidotransferase from Phaseolus aureus. Plant Physiology. ,vol. 49, pp. 977- 981 ,(1972) , 10.1104/PP.49.6.977