Espèces réactives de l'oxygène : Comment l'oxygène peut-il devenir toxique ?

作者: Monique Gardes-Albert , Daniel Jore , Zohreh Abedinzadeh , Dominique Bonnefont-Rousselot

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摘要: Reactive oxygen species. How may become toxic? Dysfunctions of metabolism generate an excess very reactive chemical species known as « » (ROS), among them are free radicals (like .OH, O 2 . - , RO ), and non-radical products H H). These species, particularly the radical create oxidative damages on biological macromolecules (DNA, lipids, proteins), which can considerably disturb cell machinery. Oxidative stress is involved in numerous pathologies (atherosclerosis, diabetes, neurodegenerative diseases, cancer...) aging process. Antioxidants aimed at more or less inhibiting generated by ROS. In order to better understand oxyradical-induced reactions, radiolysis a efficient method.

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