Antibodies for Nuclear Medicine Therapy

摘要: Immunoglobulin G (IgG) is a unique molecule with the capability of exquisite binding specificity. Its ability to bind antigens an integral component our immune system for clearing foreign cells from body. In some instances, mere IgG cell surface can elicit signals that trigger death. Although unconjugated antibodies have had increasing role in oncology and autoimmune disorders over past 10-15 years, 50+ has primarily been used target other compounds tumors goal illuminate surrounding normal tissues through imaging technologies, or therapy using variety cytotoxic agents, such as radionuclides, drugs, toxins, biological agents. Radioconjugates are perspective they allow both better detection also deliver dose radiation. The activity be manifested across many layers strong beta-emitters, narrower field alpha-emitters. radiolabeled approved use mostly follicular non-Hodgkin lymphoma, their effectiveness solid more challenging. This chapter provides brief overview how radioimmunoconjugates progressed potential future.