Pathophysiology of the Blood–Spinal Cord Barrier in Traumatic Injury
作者： HARI SHANKER SHARMA
DOI: 10.1016/B978-012639011-7/50027-9
关键词:
摘要: Abstract Trauma to the spinal cord is associated with breakdown of blood–spinal barrier (BSCB). However, detailed mechanisms and pathophysiological significance BSCB disruption in injury (SCI) are still unclear. It appears that several secondary factors release neurochemicals contribute breakdown, leading vasogenic edema formation cell injury. This review critically examines this hypothesis based on recent findings our own investigations. New data suggest trauma–induced instrumental pathology. Thus, drugs or compounds attenuating SCI could be promising therapeutic agents near future.
sci-hub.se 参考文章(479)
Bucy Pc, Green Ba, Wagner Fc, Spinal cord edema associated with paraplegia. Proceedings. Veterans Administration Spinal Cord Injury Conference. ,vol. 18, pp. 9- 10 ,(1971)
Joseph Hughes, Herbert S. Gasser, SOME PROPERTIES OF THE CORD POTENTIALS EVOKED BY A SINGLE AFFERENT VOLLEY American Journal of Physiology-Legacy Content. ,vol. 108, pp. 295- 306 ,(1934) , 10.1152/AJPLEGACY.1934.108.2.295
George M. Austin, Grayson P. McCouch, Presynaptic component of intermediary cord potential. Journal of Neurophysiology. ,vol. 18, pp. 441- 451 ,(1955) , 10.1152/JN.1955.18.5.441
de la Torre Jc, Evaluation of brain death using somatosensory evoked potentials. Biological Psychiatry. ,vol. 16, pp. 931- 935 ,(1981)
Ruth A. Rawson, THE BINDING OF T-1824 AND STRUCTURALLY RELATED DIAZO DYES BY THE PLASMA PROTEINS American Journal of Physiology-Legacy Content. ,vol. 138, pp. 708- 717 ,(1943) , 10.1152/AJPLEGACY.1943.138.5.708
Chun C. Kao, Louis W. Chang, James M. B. Bloodworth, The mechanism of spinal cord cavitation following spinal cord transection: Part 2: Electron microscopic observations Journal of Neurosurgery. ,vol. 46, pp. 745- 756 ,(1977) , 10.3171/JNS.1977.46.6.0745
H.S. Sharma, Y. Olsson, J. Cerv�s-Navarro, p-Chlorophenylalanine, a serotonin synthesis inhibitor, reduces the response of glial fibrillary acidic protein induced by trauma to the spinal cord. An immunohistochemical investigation in the rat. Acta Neuropathologica. ,vol. 86, pp. 422- 427 ,(1993) , 10.1007/BF00228575
H.S. Sharma, Y. Olsson, J. Cerv�s-Navarro, Early perifocal cell changes and edema in traumatic injury of the spinal cord are reduced by indomethacin, an inhibitor of prostaglandin synthesis : experimental study in the rat Acta Neuropathologica. ,vol. 85, pp. 145- 153 ,(1993) , 10.1007/BF00227761
H. S. Sharma, J. Westman, Y. Olsson, O. Johansson, P. K. Dey, Increased 5-hydroxytryptamine immunoreactivity in traumatized spinal cord : an experimental study in the rat Acta Neuropathologica. ,vol. 80, pp. 12- 17 ,(1990) , 10.1007/BF00294216
Ov Batson, The vertebral vein system as a mechanism for the spread of metastases AJR. ,vol. 48, pp. 715- 718 ,(1942)