Properties of mammalian tissue-bound semicarbazide-sensitive amine oxidase: possible clues to its physiological function?

摘要: Semicarbazide-sensitive amine oxidase (SSAO), occurs not only in vascular smooth muscle but also other cell types (e.g. adipocytes, chondrocytes, odontoblasts), probably the plasma membrane. Although certain aromatic biogenic amines tryptamine, tyramine, s-phenyl-ethylamine) may be endogenous substrates for SSAO species such as rat, weak activity of human tissues towards these makes this less likely man. However and rat homogenates readily converts aliphatic methylamine aminoacetone to formaldehyde methylglyoxal, respectively. Also xenobiotic allylamine produces cardiovascular damage experimental animals by a mechanism which involves its deamination acrolein. Further metabolism toxic aldehydes involve glutathione-dependent pathways. Thus, involved removal physiologically-active endogenous/xenobiotic amines, resulting metabolite (aldehyde/H2O2?) formation could influence cellular function.