Bioinformatics Analysis of Key micro-RNAs and mRNAs under the Hand, Foot, and Mouth Disease Virus Infection.
作者： SHENG LIN , LIU YANG , SHIBIAO WANG , BIN WENG , MIN LIN
关键词:
摘要: To clarify crucial key micro-RNAs and mRNAs associated with hand, foot, mouth disease (HFMD) virus infection, we conducted this bioinformatics analysis from four GEO datasets. The following datasets were used for the analysis: GSE85829, GSE94551, GSE52780, GSE45589. Differentially expressed genes (DEGs) acquired, of functional pathway enrichment relative regulatory network conducted. After screening common differentially miRNAs (DE-miRNAs), five acquired: miR-100-3p, miR-125a-3p, miR-1273g-3p, miR-5585-3p, miR-671-5p. There three enriched GO terms between miRNA-derived prediction mRNA-derived biosynthetic process, cytosol, nucleoplasm. was one KEGG pathway, i.e., cell cycle shared miRNA-based mRNA-based enrichment. Using TarBase V8 in DIANA tools, acquired 1,520 potential targets (mRNA) DE-miRNAs, among which the159 DE-mRNAs also included 11 DEGs. These DEGs showed a PPI mainly connected by SMC1A, SMARCC1, SF3B3, LIG1, BRMS1L. Together, changes may play roles HFMD progression. A combination these benefit early diagnosis treatment HFMD.
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pjmonline.org 参考文章(22)
Karolina Kaminska, Gladys Martinetti, Renzo Lucchini, Gürkan Kaya, Carlo Mainetti, Coxsackievirus A6 and Hand, Foot and Mouth Disease: Three Case Reports of Familial Child-to-Immunocompetent Adult Transmission and a Literature Review. Case Reports in Dermatology. ,vol. 5, pp. 203- 209 ,(2013) , 10.1159/000354533
Yuxuan Fu, Wentao Xu, Deyan Chen, Chunhong Feng, Li Zhang, Xiaohui Wang, Xiaowen Lv, Nan Zheng, Yu Jin, Zhiwei Wu, Enterovirus 71 induces autophagy by regulating has-miR-30a expression to promote viral replication Antiviral Research. ,vol. 124, pp. 43- 53 ,(2015) , 10.1016/J.ANTIVIRAL.2015.09.016
Hong-Ling Jia, Chun-Hui He, Zhuo-Ya Wang, Yu-Fen Xu, Gen-Quan Yin, Li-Jia Mao, Chao-Wu Liu, Li Deng, MicroRNA expression profile in exosome discriminates extremely severe infections from mild infections for hand, foot and mouth disease. BMC Infectious Diseases. ,vol. 14, pp. 506- 506 ,(2014) , 10.1186/1471-2334-14-506
Shih-Min Wang, I-Chun Chen, Yu-Ting Liao, Ching-Chuan Liu, The Clinical Correlation of Regulatory T Cells and Cyclic Adenosine Monophosphate in Enterovirus 71 Infection PLoS ONE. ,vol. 9, pp. e102025- ,(2014) , 10.1371/JOURNAL.PONE.0102025
Lunbiao Cui, Yuhua Qi, Haijing Li, Yiyue Ge, Kangchen Zhao, Xian Qi, Xiling Guo, Zhiyang Shi, Minghao Zhou, Baoli Zhu, Yan Guo, Jun Li, Charles W. Stratton, Yi-Wei Tang, Hua Wang, Serum MicroRNA Expression Profile Distinguishes Enterovirus 71 and Coxsackievirus 16 Infections in Patients with Hand-Foot-and-Mouth Disease PLOS ONE. ,vol. 6, ,(2011) , 10.1371/JOURNAL.PONE.0027071
Carlos Omaña-Cepeda, Andrea Martínez-Valverde, María del Mar Sabater- Recolons, Enric Jané-Salas, Antonio Marí-Roig, José López-López, A literature review and case report of hand, foot and mouth disease in an immunocompetent adult BMC Research Notes. ,vol. 9, pp. 165- 165 ,(2016) , 10.1186/S13104-016-1973-Y
Wee Ming Koh, Tiffany Bogich, Karen Siegel, Jing Jin, Elizabeth Y. Chong, Chong Yew Tan, Mark IC Chen, Peter Horby, Alex R. Cook, The Epidemiology of Hand, Foot and Mouth Disease in Asia The Pediatric Infectious Disease Journal. ,vol. 35, pp. e285- e300 ,(2016) , 10.1097/INF.0000000000001242
Zheng Zhu, Yuhua Qi, Huan Fan, Lunbiao Cui, Zhiyang Shi, Systematic Identification and Bioinformatic Analysis of MicroRNAs in Response to Infections of Coxsackievirus A16 and Enterovirus 71 BioMed Research International. ,vol. 2016, pp. 4302470- ,(2016) , 10.1155/2016/4302470
Yajie Hu, Jie Song, Longding Liu, Jing Li, Beibei Tang, Jingjing Wang, Xiaolong Zhang, Ying Zhang, Lichun Wang, Yun Liao, Zhanlong He, Qihan Li, Different microRNA alterations contribute to diverse outcomes following EV71 and CA16 infections: Insights from high-throughput sequencing in rhesus monkey peripheral blood mononuclear cells The International Journal of Biochemistry & Cell Biology. ,vol. 81, pp. 20- 31 ,(2016) , 10.1016/J.BIOCEL.2016.10.011
Pinn Yee, Chit Poh, Development of Novel miRNA-based Vaccines and Antivirals against Enterovirus 71. Current Pharmaceutical Design. ,vol. 22, pp. 6694- 6700 ,(2017) , 10.2174/1381612822666160720165613