Protracted infusion of 5-FU with weekly low-dose cisplatin as second-line therapy in patients with metastatic colorectal cancer who have failed 5-FU monotherapy.
作者： James D. Ahlgren , Orrawin Trocki , John J. Gullo , Richard Goldberg , W. Angus Muir
DOI: 10.3109/07357909109032797
关键词:
摘要: AbstractForty four patients who had documented progression of mestastatic colorectal cancer while receiving 5-fluorouracil (5-FU) monotherapy were treated with continuous infusion 5-FU, 300 mg/mg2/day, plus weekly low-dose cisplatin, 20 mg/m2. Treatment was given in 12-week cycles, consisting 8 weeks chemotherapy followed by a 4-week rest period, and well tolerated. Three 23 (13%) failed bolus 5-FU but not been exposed previously to infusional responded. Of 21 55-FU monotherapy, only one (5%) Time (5.7 vs. 1.8 months) survival (12 5.5 significantly longer for received schedules, compared (p <.001).
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