μ1B, a novel adaptor medium chain expressed in polarized epithelial cells1

摘要: The apical and basolateral plasma membrane domains of polarized epithelial cells contain distinct sets integral proteins. Biosynthetic targeting proteins to the is mediated by cytosolic tail determinants, many which resemble signals involved in rapid endocytosis or lysosomal targeting. Since these are recognized adaptor proteins, we hypothesized that there could be epithelial-specific adaptors sorting. Here, report identification a novel member medium chain family, named μ1B, closely related previously described μ1A (79% amino acid sequence identity). Northern blotting situ hybridization analyses reveal specific expression μ1B mRNA subset exocrine cells. Yeast two-hybrid show capable interacting with generic tyrosine-based sorting signals. These observations suggest may protein events