Periodontitis and pulmonary function: a Mendelian randomization study.

摘要: OBJECTIVES Observational research suggests that periodontitis affects pulmonary function; however, observational studies are subject to confounding and reverse causation, making causal inference the direction of these associations difficult. We used Mendelian randomization (MR) assess potential association between genetic liability function. MATERIALS AND METHODS six single-nucleotide polymorphisms (SNPs) associated with (P < 5 × 10-6) from a genome-wide study (GWAS) 17,353 European descent cases 28,210 controls GeneLifestyle Interactions in Dental Endpoints consortium UK Biobank, related SNPs lung function GWAS including 79,055 participants SpiroMeta Consortium. RESULTS MR analysis suggested no effect on ratio forced expiratory volume one second lower vital capacity (standard deviation increment outcome per doubling odds exposure (95% confidence interval) =  - 0.004 (- 0.028; 0.020)). Replication using instruments two different sensitivity analyses address pleiotropy led substantial changes estimates. CONCLUSIONS Collectively, findings do not support relationship for CLINICAL RELEVANCE Periodontitis does seem be risk factor worsening