Contribution of asymmetric synapse loss to lateralizing clinical deficits in frontotemporal dementias.

摘要: Background Synapse loss has been found to be the major correlate of cognitive decline in Alzheimer disease (AD), and prefrontal synapse patients with frontotemporal dementia (FTD). Objective To see if our hypothesis that within each FTD case, regional would lateralizing neuropsychologic neurobehavioral deficits correct. Design We analyzed synaptophysin as a marker for snap-frozen brain samples, using an enzyme-linked immunosorbent assay technique. Quantitative results were obtained by comparing patient data standard curve made analyzing serial dilutions recombinant protein fragment. A board-certified neuropsychologist neurologist, both unaware results, determined areas primary dysfunction. Relationships between dysfunction binomial test. Patients Six cases FTD, 28 AD, 16 nondemented control subjects. Results Five 6 had synaptophysins correlating frontal or temporal deficits. Three correlated 2 more regions. Although higher than expected based on pure-chance mechanism (50% vs 34%), statistical significance was not attained. Conclusions trend association FTD. Studies larger numbers are planned goal attaining statistically significant conclusions.