DNA Repair and its influence on points of departure for alkylating agent genotoxicity

摘要: Answering the question of whether low doses DNA-reactive genotoxicants are negligible concern has become a global effort due to its central importance in human health risk assessments. As result, huge amount data exists suggesting that can be tolerated, and do not increase mutagenic or carcinogenic load. Investigations have turned source this tolerance examined cytoprotective mechanisms, which may prevent mutagenesis cancer at contribute point departure (PoD). DNA repair received most attention, particularly relation PoD for alkylating agents. Data using knockout models highlight protective role doses. In where been abrogated, is either absent (linear dose-response) significantly reduced. chapter, we examine influence on agent genotoxicity.