Irregular 24-hour activity rhythms and the metabolic syndrome in older adults.

摘要: Circadian rhythms – near 24 h intrinsic biological modulate many aspects of human physiology and hence disruption circadian may have an important impact on health. Experimental work supports a potential link between irregular several key risk factors for cardiovascular disease including hypertension, obesity, diabetes dyslipidemia, collectively termed the metabolic syndrome. While epidemiological studies demonstrated association shift-work components syndrome in working-age adults, there is relative paucity data concerning non-occupational irregularity older women men. To address this question, we studied 7 days actigraphic from 1137 woman men participating Rush Memory Aging Project, community-based cohort study chronic conditions aging. The regularity activity was quantified using nonparametric interdaily stabilit...