Bifunctional Asymmetric Catalysis with Hydrogen Chloride: Enantioselective Ring-Opening of Aziridines Catalyzed by a Phosphinothiourea.
作者： Eric Jacobsen , Tsuyoshi Mita
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摘要: Ring-opening of aziridines with hydrogen chloride to form β-chloroamine derivatives is catalyzed by a chiral phosphinothiourea derivative in high yields and enantioselectivities. On the basis 31P NMR studies, activation HCl appears proceed via quantitative protonation catalyst afford phosphonium complex.
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