Hydrogen-Bond-Promoted Hetero-Diels−Alder Reactions of Unactivated Ketones

作者: Yong Huang , Viresh H. Rawal

DOI: 10.1021/JA0267627

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摘要: We report the first examples of hydrogen-bond-promoted acceleration hetero-Diels-Alder reactions and use such catalysis for simple, unactivated ketones. Several spiro-fused dihydropyans were synthesized in good yields using this procedure. This activation protocol represents an attractive operationally simple alternative to conventional, Lewis acid catalysis.

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