In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases

摘要: Potent, selective, and cell active small molecule kinase inhibitors are useful tools to help unravel the complexities of signaling. As biological functions individual kinases become better understood, they can targets drug discovery efforts. The molecules used shed light on function also then serve as chemical starting points in these Nek family has received very little attention, judged by number citations PubMed, yet appear play many key roles have been implicated disease. Here we present our work identify high quality that emerged due increased incidence broad kinome screening. We anticipate this analysis will allow community progress towards generation probes eventually drugs target members family.