Transgenic mice comprising a constitutively-activated MEK5 and exhibiting cardiac hypertrophy and dilated cardiomyopathy
作者： Eric N. Olson , Rebekka Nicol
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摘要: The present invention relates to compositions and methods relating MEK5 its role in heart disease. This protein has now been identified as a target for therapeutic intervention due molecular events that lead or contribute cardiac hypertrophy and/or dilated cardiomyopathy. In particular, inhibition of activity will decrease signalling the pathways reduce eliminate effects on sarcomere assembly, which turn result dysfunction. Also provided are transgenic animals screening inhibitors MEK5.
lens.org参考文章(30)
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