BCL-2 proteins

作者: Carlo A. Croce , Yoshihide Tsujimoto

DOI:

关键词:

摘要: The sequence of the protein coding regions bcl-2 gene are provided as well bacterial clones which produce proteins. Assays for detecting a class B-cell neoplasms associated with chromosome translocation between chromosomes 14 and 18. This is involved in majority cases human follicular lymphomas. One assay employs an antibody immunoreactive over-expressed due to translocation. Another involves measurement amount mRNA hybridizes proximal break-point.

参考文章(8)
Y Tsujimoto, J Gorham, J Cossman, E Jaffe, C. Croce, The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining Science. ,vol. 229, pp. 1390- 1393 ,(1985) , 10.1126/SCIENCE.3929382
L. Pegoraro, A. Palumbo, J. Erikson, M. Falda, B. Giovanazzo, B. S. Emanuel, G. Rovera, P. C. Nowell, C. M. Croce, A 14;18 and an 8;14 chromosome translocation in a cell line derived from an acute B-cell leukemia Proceedings of the National Academy of Sciences of the United States of America. ,vol. 81, pp. 7166- 7170 ,(1984) , 10.1073/PNAS.81.22.7166
Y Tsujimoto, J Cossman, E Jaffe, C. Croce, Involvement of the bcl-2 gene in human follicular lymphoma Science. ,vol. 228, pp. 1440- 1443 ,(1985) , 10.1126/SCIENCE.3874430
M. L. Cleary, J. Sklar, Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 7439- 7443 ,(1985) , 10.1073/PNAS.82.21.7439
M. M. Bashir, I. Givol, J. Cossman, E. Jaffe, C. M. Croce, Y. Tsujimoto, DNA rearrangements in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 1329- 1331 ,(1987) , 10.1073/PNAS.84.5.1329
Y. Tsujimoto, E. Jaffe, J. Cossman, J. Gorham, P. C. Nowell, C. M. Croce, Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation. Nature. ,vol. 315, pp. 340- 343 ,(1985) , 10.1038/315340A0
Y. Tsujimoto, C. M. Croce, Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 5214- 5218 ,(1986) , 10.1073/PNAS.83.14.5214
Y Tsujimoto, L. Finger, J Yunis, P. Nowell, C. Croce, Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation Science. ,vol. 226, pp. 1097- 1099 ,(1984) , 10.1126/SCIENCE.6093263