Differential inhibitory effects of vitamin E and other antioxidants on prostaglandin synthetase, platelet aggregation and lipoxidase
作者： Rao V. Panganamala , James S. Miller , Ephraim T. Gwebu , Hari M. Sharma , David G. Cornwell
DOI: 10.1016/0090-6980(77)90171-X
关键词:
摘要: Abstract Prostaglandin biosynthesis from eicosa-8,11,14-trienoic acid in microsomes the bovine vesicular gland is inhibited by antioxidants α-naphthol, guaiacol, NDGA and propyl gallate. this system not BHT, DL-α-tocopherol Trolox C. Arachidonic induced platelet aggregation specifically Both arachidonic ADP are non-specifically All tested study inhibit soybean lipoxidase. Thus gallate non-specific inhibitors of both prostaglandin synthetase lipoxidase while C specific alone.
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sci-hub.se 参考文章(19)
Paul György, Rudolph M. Tomarelli, Further observations on physiological antioxidants. Journal of Biological Chemistry. ,vol. 154, pp. 317- 324 ,(1944) , 10.1016/S0021-9258(18)71912-1
J W Lagocki, E A Emken, J H Law, F J Kézdy, Kinetic analysis of the action of soybean lipoxygenase on linoleic acid. Journal of Biological Chemistry. ,vol. 251, pp. 6001- 6006 ,(1976) , 10.1016/S0021-9258(17)33050-8
Rao V. Panganamala, Hari M. Sharma, Howard Sprecher, Jack C. Geer, David G. Cornwell, A suggested role for hydrogen peroxide in the biosynthesis of prostaglandins Prostaglandins. ,vol. 8, pp. 3- 11 ,(1974) , 10.1016/0090-6980(74)90031-8
J. A. Blain, G. Shearer, Inhibition of soya lipoxidase Journal of the Science of Food and Agriculture. ,vol. 16, pp. 373- 378 ,(1965) , 10.1002/JSFA.2740160702
A.L. Tappel, W.O. Lundberg, P.D. Boyer, Effect of temperature and antioxidants upon the lipoxidase-catalyzed oxidation of sodium linoleate Archives of Biochemistry and Biophysics. ,vol. 42, pp. 293- 304 ,(1953) , 10.1016/0003-9861(53)90359-2
Rao V. Panganamala, Nicholas R. Brownlee, Howard Sprecher, David G. Cornwell, Evaluation of superoxide anion and singlet oxygen in the biosynthesis of prostaglandins from eicosa-8,11,14-trienoic acid. Prostaglandins. ,vol. 7, pp. 21- 28 ,(1974) , 10.1016/S0090-6980(74)80074-2
Mats Hamberg, On the formation of thromboxane B2 and 12l-hydroxy-5,8,10,14-eicosatetraenoic acid (12 ho-20:4) in tissues from the guinea pig. Biochimica et Biophysica Acta. ,vol. 431, pp. 651- 654 ,(1976) , 10.1016/0005-2760(76)90232-0
M Steiner, J Anastasi, Vitamin E. An inhibitor of the platelet release reaction. Journal of Clinical Investigation. ,vol. 57, pp. 732- 737 ,(1976) , 10.1172/JCI108331
W. M. Cort, J. W. Scott, M. Araujo, W. J. Mergens, M. A. Cannalonga, M. Osadca, H. Harley, D. R. Parrish, W. R. Pool, Antioxidant activity and stability of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid Journal of the American Oil Chemists' Society. ,vol. 52, pp. 174- 178 ,(1975) , 10.1007/BF02672164
Donald T. Downing, Differential inhibition of prostaglandin synthetase and soybean lipoxygenase Prostaglandins. ,vol. 1, pp. 437- 441 ,(1972) , 10.1016/0090-6980(72)90012-3