Microvascular complications in orthokeratology (Ortho-K): A real-time study on the microvasculature of the bulbar conjunctiva in Ortho-K treatment

摘要: Orthokeratology (Ortho-K) is an over-night hard contact lens therapy, which physically reshapes the corneal curvature in order to stabilize or temporally eliminate myopia patients. We hypothesize that prolonged physical and mechanical pressure induced by Ortho-K lenses may create lasting inadvertent effects damages (microangiopathy), bring about unwanted changes microvasculature of bulbar conjunctiva. Computer-assisted intravital microscopy (CAIM) was used view, document (via videotaping) objectively quantify computer-assisted image analysis) real-time dynamic morphometric characteristics conjunctival microcirculation long-term (at least over one year) patients (n = 11) matched non-user control subjects 8). were instructed wear their overnight following standard protocol. During study, left eye all users viewed, frequently re-focused videotaped, without with place, as outlined Methods. The (non-lens wearing) videotaped studied like manner. each user subject analyzed, quantified summated a severity index (SI) collectively for comparison. SI (4.18±1.08) differed significantly from (1.75±1.39, p≤0.05). In addition, (e.g., flow velocity, vessel diameter, shape change, etc) viewed immediately after myopic put on lenses. Eight 11 displayed significant percentage (p≤0.05) velocity 10 results clearly indicated microvascular via tissue remodeling occurred, caused directly presence