Paralytic and nonparalytic muscle adaptations to exercise training versus high-protein diet in individuals with long-standing spinal cord injury.

摘要: This study compares the effects of an 8-wk isocaloric high-protein (HP) diet versus a combination exercise (Comb-Ex) regimen on paralytic vastus lateralis (VL) and nonparalytic deltoid muscle in individuals with long-standing spinal cord injury (SCI). Fiber-type distribution, cross-sectional area (CSA), levels translation initiation signaling proteins (Erk-1/2, Akt, p70S6K1, 4EBP1, RPS6, FAK), lean thigh mass were analyzed at baseline after interventions. A total 11 participants (C5-T12 levels, 21.8 ± 6.3 yr postinjury; 6 Comb-Ex 5 HP diet) completed study. training occurred 3 days/wk consisted upper body resistance (RT) addition to neuromuscular electrical stimulation (NMES)-induced-RT for VL muscle. Strength was combined high-intensity arm-cranking exercises (1-min intervals 85-90%, Vo2peak) improving cardiovascular endurance. For intervention, protein fat each comprised 30%, carbohydrate 40% energy. Clinical tests biopsies performed 24 h before last or session. The intervention increased Type IIa myofiber distribution CSA I In addition, mass, Vo2peak, strength ( P < 0.05). These results suggest that is required promote favorable changes muscles SCI, adequate dietary consumption alone may not be sufficient ameliorate debilitating paralysis. NEW & NOTEWORTHY first directly compare clinical molecular injury. Our demonstrated growth fiber-type alterations can best achieved when paralyzed sufficiently loaded via stimulation-induced training.