Retinoic acid in alveolar development, maintenance and regeneration

摘要: Recent data suggest that exogenous retinoic acid (RA), the biologically active derivative of vitamin A, can induce alveolar regeneration in a rat model experimental emphysema. Here, we describe mouse disrupted development using dexamethasone administered postnatally. We show effects are concentration dependent, dose long lasting and result severe loss surface area. When RA is to these animals as adults, lung architecture area per unit body weight completely restored normal. This remarkable effect may be because required during normal administering re-awakens gene cascades used development. provide evidence alveologenesis by showing levels retinoid binding proteins, receptors two synthesizing enzymes peak Furthermore, an inhibitor synthesis, disulphiram, disrupts alveologenesis. also throughout life for maintenance alveoli when rats deprived dietary retinol they lose features Alveolar with therefore important novel therapeutic approach treatment respiratory diseases characterized reduced gas-exchanging such bronchopulmonary dysplasia emphysema which there currently no treatments.