Previous Aspirin Use May Attenuate the Severity of the Manifestation of Acute Ischemic Syndromes

作者: David Garcia-Dorado , Pierre Théroux , Pilar Tornos , Antonia Sambola , Juan Oliveras

DOI: 10.1161/01.CIR.92.7.1743

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摘要: Background The present study was designed to investigate whether the prior use of aspirin could influence severity manifestation acute coronary artery syndromes, given well-documented observations that can prevent myocardial infarction, stroke, and death in cardiovascular disease. Methods Results A series 539 consecutive patients admitted Coronary Care Unit a General Hospital carefully characterized with an ambidirectional design, regard previous medical history, use, subsequent hospital diagnosis. Among 214 previously taking aspirin, diagnosis infarction 24% unstable angina 76% compared 54% 46%, respectively, among 325 not (P<.0001), for reduction odds ratio 72% (95% CI, 59% 90%). decrease homogeneous all subsets studied independent age, sex, angina, or m...

参考文章(22)
W M O'Fallon, J F Keane, D J Driscoll, D R Pieroni, C J Hayes, W M Gersony, L Kidd, R R Wolfe, W H Weidman, Second natural history study of congenital heart defects. Results of treatment of patients with ventricular septal defects Circulation. ,vol. 87, pp. 38- ,(1993)
Paul M Ridker, JoAnn E Manson, Julie E Buring, Samuel Z Goldhaber, Charles H Hennekens, None, Clinical characteristics of nonfatal myocardial infarction among individuals on prophylactic low-dose aspirin therapy. Circulation. ,vol. 84, pp. 708- 711 ,(1991) , 10.1161/01.CIR.84.2.708
Marc Cohen, Jan Xiong, Gareth Parry, Philip C Adams, Douglas Chamberlain, Iwona Wieczorek, Keith AA Fox, Ruth McBrede, James H Chesebro, Valentin Fuster, Antithrombotic Therapy in Acute Coronary Syndromes Research Group, Prospective comparision of unstable angina versus non-Q wave myocardial infarction during antithrombotic therapy Journal of the American College of Cardiology. ,vol. 22, pp. 1338- 1343 ,(1993) , 10.1016/0735-1097(93)90540-H
C Ranke, H Hecker, A Creutzig, K Alexander, Dose-dependent effect of aspirin on carotid atherosclerosis. Circulation. ,vol. 87, pp. 1873- 1879 ,(1993) , 10.1161/01.CIR.87.6.1873
Theodore L. Schreiber, Gregory Macina, Paul Bunnell, Richard D. Tenney, Ann McNulty, Marie Kikel, David H. Miller, Benjamin E. Zola, Russell Tracy, David Stump, Unstable angina or non-Q wave infarction despite long-term aspirin: Response to thrombolytic therapy with implications on mechanisms American Heart Journal. ,vol. 120, pp. 248- 255 ,(1990) , 10.1016/0002-8703(90)90066-7
Paul M Ridker, JoAnn E Manson, Julie E Buring, Samuel Z Goldhaber, Charles H Hennekens, None, The effect of chronic platelet inhibition with low-dose aspirin on atherosclerotic progression and acute thrombosis: clinical evidence from the Physicians' Health Study. American Heart Journal. ,vol. 122, pp. 1588- 1592 ,(1991) , 10.1016/0002-8703(91)90275-M
Pierre Théroux, Rosa-Maria Lidón, Unstable angina: Pathogenesis, diagnosis, and treatment Current Problems in Cardiology. ,vol. 18, pp. 162- 231 ,(1993) , 10.1016/0146-2806(93)90016-U