Issues in Pre-clinical Models, Clinical Trial Design and Analytical Considerations in Developing and Evaluating Novel Cancer Immunotherapies

摘要: The role of the immune system in detecting and killing cancer cells has been understood for decades1–3. human an innate ability to arrest carcinogenesis; however, some cases, this fails due a series mechanisms that tumor use escape surveillance, such as mimicking normal cells, producing immunosuppressive growth factors cytokines, or forming complex immunological interactions4. Differences clinical responses immunotherapy differ sufficiently from cytotoxic agents many aspects trial design must be re-thought, subject chapter.