Effects of growth hormone on lipid metabolism in humans
作者： Niels Møller , Jakob Gjedsted , Lars Gormsen , Jens Fuglsang , Christian Djurhuus
DOI: 10.1016/S1096-6374(03)00048-0
关键词:
摘要: The most immediate effect of growth hormone (GH) administration in humans is a significant increase free fatty acids after 1-2 h, reflecting stimulation lipolysis and ketogenesis. This represents an important physiological adaptation to stress fasting. When the capacity GH blocked, protein-retaining insulin-antagonistic effects on glucose metabolism are either abolished or weakened dramatically, compatible with key role for orchestrating metabolic actions GH.
elsevier.com
sci-hub.se 参考文章(48)
D G Johnston, R R Davies, R W G Prescott, Regulation of growth hormone secretion in man: a review. Journal of the Royal Society of Medicine. ,vol. 78, pp. 319- 327 ,(1985) , 10.1177/014107688507800410
Wilmore Dw, Manson Jm, Positive nitrogen balance with human growth hormone and hypocaloric intravenous feeding. Surgery. ,vol. 100, pp. 188- 197 ,(1986)
Mayer B. Davidson, Jack M. Bernstein, The effect of nicotinic acid on growth hormone-induced lipolysis and glucose intolerance. Journal of Laboratory and Clinical Medicine. ,vol. 81, pp. 568- 576 ,(1973) , 10.5555/URI:PII:0022214373902369
B Richelsen, Effect of growth hormone on adipose tissue and skeletal muscle lipoprotein lipase activity in humans. Journal of Endocrinological Investigation. ,vol. 22, pp. 10- 15 ,(1999)
Aa. P. Hansen, K. Johansen, Diurnal patterns of blood glucose, serum free fatty acids, insulin, glucagon and growth hormone in normals and juvenile diabetics Diabetologia. ,vol. 6, pp. 27- 33 ,(1970) , 10.1007/BF00425888
D. A. Fryburg, R. A. Gelfand, E. J. Barrett, Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans American Journal of Physiology-endocrinology and Metabolism. ,vol. 260, ,(1991) , 10.1152/AJPENDO.1991.260.3.E499
N. Moller, J. O. Jorgensen, O. Schmitz, J. Moller, J. Christiansen, K. G. Alberti, H. Orskov, Effects of a growth hormone pulse on total and forearm substrate fluxes in humans. American Journal of Physiology-endocrinology and Metabolism. ,vol. 258, ,(1990) , 10.1152/AJPENDO.1990.258.1.E86
M. L. Hartman, A. C. Faria, M. L. Vance, M. L. Johnson, M. O. Thorner, J. D. Veldhuis, Temporal structure of in vivo growth hormone secretory events in humans American Journal of Physiology-endocrinology and Metabolism. ,vol. 260, pp. 5101- 5110 ,(1991) , 10.1152/AJPENDO.1991.260.1.E101
R. A. Rizza, L. J. Mandarino, J. E. Gerich, Effects of Growth Hormone on Insulin Action in Man: Mechanisms of Insulin Resistance, Impaired Suppression of Glucose Production, and Impaired Stimulation of Glucose Utilization Diabetes. ,vol. 31, pp. 663- 669 ,(1982) , 10.2337/DIAB.31.8.663
KENNETH L. ZIERLER, DAVID RABINOWITZ, ROLES OF INSULIN AND GROWTH HORMONE, BASED ON STUDIES OF FOREARM METABOLISM IN MAN. Medicine. ,vol. 42, pp. 385- 402 ,(1963) , 10.1097/00005792-196311000-00002