Lymphocytes, neutrophils and serum immunoglobulins in patients with precancerous states of the larynx.

摘要: In 24 men aged 32 to 58 years with precancerous states of the larynx, i.e., leukoplakia, papillomas and pachydermia peripheral blood lymphocytes were cytochemically stained for N-acetyl-beta-glucosaminidase, beta-glucuronidase, acid phosphatase glycogen; neutrophils alkaline phosphatase, myeloperoxidase lipids. The results expressed in terms absolute counts reaction-positive cells activity index score. serum immunoglobulins IgG, IgA IgM also determined by Mancini's method. obtained compared those 20 healthy 30 years. patients exhibited elevated numbers N-acetyl-beta-glucosaminidase beta-glucuronidase-positive lymphocytes. A characteristic feature was an increase diffuse granular-diffuse types cytochemical reaction all enzymes studied. number granular type enzymatic (intact enzyme-positive lysosomes) significantly diminished. These alterations accompanied a significant level. are discussed reference lymphoid system response tissues lesions larynx. So far as concerned intracellular deficiency beta-glucuronidase decrease lipid content well activity. possible significance diminished cytotoxic these against tumor lesion is discussed.