Nickel exposure alters behavioral parameters in larval and adult zebrafish.

摘要: Abstract Nickel is a heavy metal that, at high concentrations, leads to environmental contamination and causes health problems. We evaluated the effects of NiCl2 exposure on cognition behavior in larval adult zebrafish. Larval zebrafish were exposed concentrations (0.025, 2.0, 5.0, 15.0 mg/L) or water (control) two treatment regimens: acute subchronic. Larvae for 2 h (acute treatment: 5-day-old larvae treated 2 h, tested after treatment) 11 days (subchronic 11-day-old since fertilization, 5, 8 post-fertilization, dpf). Adults 12 h 96 h period. In both regimens, showed concentration-dependent increases body nickel levels compared with controls. For larvae, delayed hatching, decreased heart rate morphological alterations observed subchronically from subchronic 5 dpf decrease distance mean speed low concentration (0.025 mg/L) increased higher (5.0 15.0 mg/L). Subchronic locomotion 15.0 mg/L 11 dpf, whereas escape responses an aversive stimulus was 5.0 all developmental stages. adults, exploratory test that induced anxiogenic-like aggression, impaired memory treatments. These results indicate early life stages alterations, avoidance response impairment locomotor deficits adults resulst anxiogenic effects, aggressive behavior. may be associated neurotoxic actions suggest this influence animals' physiology doses do not necessarily impact their survival.