Age as a risk factor for stroke in atrial fibrillation patients: implications for thromboprophylaxis.

摘要: The prevalence of atrial fibrillation (AF) is related to age and projected rise exponentially as the population ages cardiovascular risk factors increases. ischemic stroke significantly increased in AF patients, there evidence a graded associated with advancing age. Oral anticoagulation (OAC) far more effective than antiplatelet agents at reducing patients AF. Therefore, increasing numbers elderly are candidates for, could benefit from, use anticoagulants. However, people less likely receive OAC therapy. This mainly due concerns about higher OAC-associated hemorrhage population. Until recently, older were under-represented randomized controlled trials versus placebo or therapy, therefore base for value was not known. analyses available trial data indicate that expected net clinical warfarin therapy highest among untreated stroke, which includes oldest category. An important caveat treatment maintenance therapeutic international normalized ratio, regardless patient, where time range should be ≥65%. alone prevent prescription given an appropriate bleeding stratification.