Reactivation of resolved infection with the hepatitis B virus immune escape mutant G145R during dasatinib treatment for chronic myeloid leukemia
作者： Toshihiko Ando , Kensuke Kojima , Hiroshi Isoda , Yuichiro Eguchi , Takashi Honda
DOI: 10.1007/S12185-015-1788-Y
关键词:
摘要: Reactivation of hepatitis B virus (HBV) following immunosuppressive therapy or hematopoietic stem cell transplantation is a potentially fatal complication that may occur even in patients with prior resolution HBV infection. Dasatinib small-molecule inhibitor the tyrosine kinases SRC and ABL has been approved for treatment chronic myeloid leukemia (CML) Philadelphia chromosome-positive acute lymphoblastic leukemia. Here, we report first case reactivation resolved infection immune escape mutant G145R CML patient receiving dasatinib. Although dasatinib not recognized as an immunosuppressant, our observations suggest enhance replication induce its immunocompetent patients, mutants contribute to pathogenesis reactivation, close monitoring status advisable current
springer.com
sci-hub.se 参考文章(28)
Masatoshi Ishigami, Takashi Honda, Yoji Ishizu, Yasuharu Onishi, Hideya Kamei, Kazuhiko Hayashi, Yasuhiro Ogura, Yoshiki Hirooka, Hidemi Goto, Frequent incidence of escape mutants after successful hepatitis B vaccine response and stopping of nucleos(t)ide analogues in liver transplant recipients. Liver Transplantation. ,vol. 20, pp. 1211- 1220 ,(2014) , 10.1002/LT.23935
Hiroshi Kamitsukasa, Masanobu Iri, Akihisa Tanaka, Shigeo Nagashima, Masaharu Takahashi, Tsutomu Nishizawa, Hiroaki Okamoto, Spontaneous reactivation of hepatitis B virus (HBV) infection in patients with resolved or occult HBV infection Journal of Medical Virology. ,vol. 87, pp. 589- 600 ,(2015) , 10.1002/JMV.24115
Timm H. Westhoff, Friederike Jochimsen, Alexander Schmittel, Marina Stöffler-Meilicke, Jürgen H. Schäfer, Walter Zidek, Wolfram H. Gerlich, Eckhard Thiel, Fatal hepatitis B virus reactivation by an escape mutant following rituximab therapy Blood. ,vol. 102, pp. 1930- 1930 ,(2003) , 10.1182/BLOOD-2003-05-1403
YUN-FAN LIAW, Hepatitis viruses under immunosuppressive agents Journal of Gastroenterology and Hepatology. ,vol. 13, pp. 14- 20 ,(1998) , 10.1111/J.1440-1746.1998.TB00539.X
A Kreutzman, K Ladell, C Koechel, E Gostick, M Ekblom, L Stenke, T Melo, H Einsele, K Porkka, D A Price, S Mustjoki, R Seggewiss, Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation Leukemia. ,vol. 25, pp. 1587- 1597 ,(2011) , 10.1038/LEU.2011.135
Barbara Rehermann, Carlo Ferrari, Claudio Pasquinelli, Francis V. Chisari, The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T–lymphocyte response Nature Medicine. ,vol. 2, pp. 1104- 1108 ,(1996) , 10.1038/NM1096-1104
Shin Fujisawa, Hirohisa Nakamae, Michinori Ogura, Ken-ichi Ishizawa, Masafumi Taniwaki, Atae Utsunomiya, Kosei Matsue, Yasushi Takamatsu, Kensuke Usuki, Mitsune Tanimoto, Yoji Ishida, Hideki Akiyama, Shintaro Onishi, Efficacy and safety of dasatinib versus imatinib in Japanese patients with newly diagnosed chronic-phase chronic myeloid leukemia (CML-CP): Subset analysis of the DASISION trial with 2-year follow-up International Journal of Hematology. ,vol. 99, pp. 141- 153 ,(2014) , 10.1007/S12185-013-1470-1
Michinori Aoe, Akira Shimada, Michiko Muraoka, Kana Washio, Yoshimi Nakamura, Takahide Takahashi, Masahide Imada, Toshiyuki Watanabe, Ken Okada, Ritsuo Nishiuchi, Takako Miyamura, Kosuke Chayama, Misako Shibakura, Megumi Oda, Tsuneo Morishima, ABL kinase mutation and relapse in 4 pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia cases International Journal of Hematology. ,vol. 99, pp. 609- 615 ,(2014) , 10.1007/S12185-014-1565-3
K. Ikeda, Y. Shiga, A. Takahashi, T. Kai, H. Kimura, K. Takeyama, H. Noji, K. Ogawa, A. Nakamura, H. Ohira, Y. Sato, Y. Maruyama, Fatal hepatitis B virus reactivation in a chronic myeloid leukemia patient during imatinib mesylate treatment Leukemia & Lymphoma. ,vol. 47, pp. 155- 157 ,(2006) , 10.1080/14639230500236818
M Wölfl, F Langhammer, V Wiegering, M Eyrich, P G Schlegel, Dasatinib medication causing profound immunosuppression in a patient after haploidentical SCT: functional assays from whole blood as diagnostic clues Bone Marrow Transplantation. ,vol. 48, pp. 875- 877 ,(2013) , 10.1038/BMT.2012.246