Interactions Between Wnt/β-Catenin/Fgf and Chemokine Signaling in Lateral Line Morphogenesis

摘要: Publisher Summary In order for proper morphogenesis to occur, a variety of cellular behaviors have be tightly coordinated (e.g., cell migration, cell–cell adhesion, proliferation, death, interactions with the environment, and changes in morphology). Because this complexity, molecular biological mechanisms that regulate embryonic remain poorly understood. Different signaling pathways interact each other control morphogenesis. On top cascade is Wnt/β-catenin leading cells, which initiates feedback loop between itself Fgf trailing cells. The restriction these regionally distinct domains ensures coupling neurogenesis directed migration all cells within primordium. Each pathway induces expression inhibitors pathway. This justifies reinvestigation hierarchy organ systems. Even though exact nature molecules might not exactly recapitulated systems, it likely overall characteristics are conserved. Many genes been identified important lateral line development also major players cancer humans. It therefore believed that, because its relative simplicity accessibility, migrating primordium very valuable model understanding disease.