Transactivation joins multiple tracks to the ERK/MAPK cascade.
作者： Reinhard Wetzker , Frank-D. Böhmer
DOI: 10.1038/NRM1173
关键词:
摘要: Many agonists of G-protein-coupled receptors (GPCRs) can stimulate receptor tyrosine kinases and the extracellular signal-regulated kinase (ERK)/mitogen-activated protein (MAPK) pathway. A 'transactivation' mechanism, which links these events in one signalling chain, inspired many researchers, but inevitably raised new questions. 'multi-track' model for GPCR to ERK/MAPK pathway might resolve some puzzles transactivation field.
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