Stimulating factor of the neu receptor

摘要: The neu proto-oncogene encodes a transmembrane glycoprotein related to the receptor for epidermal growth factor (EGF). Purification of stimulating homogeneity from ras-transformed fibroblasts has now been achieved. Its identity as established by covalent crosslinking experiments. stimulates tyrosine phosphorylation at low concentrations. inhibits proliferation and promotes differentiation human carcinoma cells.