Pax3: A paired domain gene as a regulator in PNS myelination

摘要: Pax3 RNA is expressed in neural crest when Schwann cell (SC) precursors migrate to the PNS. and SC markers were monitored sciatic nerves of mice during development nerve repair. An inverse correlation was observed between expression myelin basic protein (MBP). Inverse also primary cultures. Treating cultures with forskolin, an adenylate cyclase agonist, repressed RNA, GFAP, NGFR, N-CAM, L1 elevated MBP. Subsequent microinjection vector Thus, likely involved differentiation pathway myelinating SCs. a 1.3 kb MBP promoter fragment cotransfection assays, suggesting that it represses transcription.