Immune Defects in Cancer

摘要: The host immune system is one of the most important elements antitumor defense. idea cancer immunosurveillance proposed by Sir Macfarlaine Burnet and Lewis Thomas (1,2) has been recently highlighted in experiments with gene knockout mice. Compared wild-type mice, mice lacking sensitivity to either interferon-γ (IFN-γ receptor-deficient mice) or all interferon (IFN) family members (i.e., Stat 1 -deficient developed tumors more rapidly greater frequency when challenged different doses chemical carcinogen methylcholanthrene (3). Mice lymphocytes IFN-γ (RAG2-/- x STAT1-/- also had an increased incidence spontaneous mammary (4). development metastatic disease nonimmunocompromised hosts can be considered as a result inadequate response against evasion tumor cells from (5). correlation between presence tumor-infiltrating survival patients melanoma (6), breast (7), bladder (8), colon (9), neuroblastoma (10), ovary (11), prostate (12) cancers gives hope that manipulation escape mechanisms, immuntherapeutic interventions, may provide clinical benefits. In tumorbearing animals patients, however, markedly depressed. fact resection progressively growing solid restores protective immunity experimental models (13) demonstrates ability defend established tumor.