作者: Dalip Kumar , Bhupendra Mishra , K. P. Chandrashekar , Santosh B. Khandagale , Mukund P. Tantak
DOI: 10.1039/C5RA03075G
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摘要: We report a facile iodine(III)-mediated synthesis of cyanoporphyrins and their DNA photocleavage activity. Cationic-porphyrin 9a showed intercalative binding towards DNA, whereas Zn(II)-cyanoporphyrinate 9b outside electrostatic as indicated by absorption emission spectra. Porphyrin displayed significant photocytotoxicity against A549 cancer cell line with an IC50 value 54 nM.