Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism.
作者： Chris Pepper , Alun Thomas , Chris Fegan , Terry Hoy , Paul Bentley
DOI: 10.1080/1042819021000029984
关键词:
摘要: Flavopiridol, a synthetic flavone, has been previously shown to induce apoptosis in B-cell chronic lymphocytic leukaemia (B-CLL) cells in vitro. The apoptosis was associated with a …
informahealthcare.com参考文章(32)
T Watanabe, T Hotta, A Ichikawa, T Kinoshita, H Nagai, T Uchida, T Murate, H Saito, The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin. Blood. ,vol. 84, pp. 3158- 3165 ,(1994) , 10.1182/BLOOD.V84.9.3158.3158
Thomas A, El Rouby S, Krajewski S, Reed Jc, Newcomb Ew, Potmesil M, Silber R, Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance. Oncogene. ,vol. 12, pp. 1055- 1062 ,(1996)
M Hanada, D Delia, A Aiello, E Stadtmauer, JC Reed, bcl-2 Gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia Blood. ,vol. 82, pp. 1820- 1828 ,(1993) , 10.1182/BLOOD.V82.6.1820.1820
E Wattel, C Preudhomme, B Hecquet, M Vanrumbeke, B Quesnel, I Dervite, P Morel, P Fenaux, p53 Mutations Are Associated With Resistance to Chemotherapy and Short Survival in Hematologic Malignancies Blood. ,vol. 84, pp. 3148- 3157 ,(1994) , 10.1182/BLOOD.V84.9.3148.3148
Hartmut Dohner, Konstanze Fischer, Martin Bentz, Katrin Hansen, Axel Benner, Georges Cabot, Daniela Diehl, Richard Schlenk, Johannes Coy, Stephan Stilgenbauer, Martin Volkmann, Peter R Galle, Annemarie Poustka, Werner Hunstein, Peter Lichter, p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias Blood. ,vol. 85, pp. 1580- 1589 ,(1995) , 10.1182/BLOOD.V85.6.1580.BLOODJOURNAL8561580
G S Worthen, G S Worthen, J A Nick, N J Avdi, P Gerwins, G L Johnson, G L Johnson, ACTIVATION OF A P38 MITOGEN-ACTIVATED PROTEIN KINASE IN HUMAN NEUTROPHILS BY LIPOPOLYSACCHARIDE Journal of Immunology. ,vol. 156, pp. 4867- 4875 ,(1996)
J Anastasi, MM Le Beau, JW Vardiman, AA Fernald, RA Larson, JD Rowley, Detection of trisomy 12 in chronic lymphocytic leukemia by fluorescence in situ hybridization to interphase cells: a simple and sensitive method Blood. ,vol. 79, pp. 1796- 1801 ,(1992) , 10.1182/BLOOD.V79.7.1796.1796
S el Rouby, A Thomas, D Costin, CR Rosenberg, M Potmesil, R Silber, EW Newcomb, p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression Blood. ,vol. 82, pp. 3452- 3459 ,(1993) , 10.1182/BLOOD.V82.11.3452.3452
J. L. Binet, A. Auquier, G. Dighiero, C. Chastang, H. Piguet, J. Goasguen, G. Vaugier, G. Potron, P. Colona, F. Oberling, M. Thomas, G. Tchernia, C. Jacquillat, P. Boivin, C. Lesty, M. T. Duault, M. Monconduit, S. Belabbes, F. Gremy, A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis Cancer. ,vol. 48, pp. 198- 206 ,(1981) , 10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V
Terrance A. Stadheim, Gregory L. Kucera, Extracellular signal-regulated kinase (ERK) activity is required for TPA-mediated inhibition of drug-induced apoptosis. Biochemical and Biophysical Research Communications. ,vol. 245, pp. 266- 271 ,(1998) , 10.1006/BBRC.1998.8410