Pharmacologic dissociation between impulsivity and alcohol drinking in High Alcohol Preferring mice

摘要: Background: Impulsivity is genetically correlated with, and precedes, addictive behaviors alcoholism. If impulsivity or attention causally related to addiction, certain pharmacological manipulations of and/or may affect alcohol drinking, vice versa. The current studies were designed explore the relationship among impulsivity, vigilance in selectively bred High Alcohol Preferring (HAP) mice, a line that has previously demonstrated both high consumption. Amphetamine, naltrexone, memantine tested delay discounting (DD) task for their effects on vigilance. same drugs doses also assessed drinking 2-bottle choice test. Methods: HAP mice subjected modified version adjusting amount DD using 0.5-second 10-second delays detect decreases increases, respectively, impulsive responding. In 2 experiments, given amphetamine (0.4, 0.8, 1.2 mg/kg), naltrexone (3 10 (1 5 mg/kg) before testing. Another pair used scheduled access, assess 1.2, 3.0 Results: Amphetamine dose-dependently reduced decrement DD, but similar left unaffected. Naltrexone decreased intake at did not water had no task. Conclusions: Contrary our hypothesis, none here, while effective either behaviors. These findings suggest genetic association between observed this population mediated by mechanisms other than those targeted these studies. Language: en