Dissolution of amorphous nifedipine from micelle-forming carboxymethylcellulose derivatives.

摘要: Abstract We show that a novel amphiphilic graft copolymer combining the biodegradability and biocompatibility of oxidized carboxymethylcellulose (CMC) with hydrophilic poly(ethylene glycol) (PEG), hydrophobic dodecylamine (DDA), improves solubility dissolution performance nifedipine (NIF), considered as model drug. The components have multiple effect favouring micelle formation loading. At same time, interaction between core NIF has secondary to suppress drug crystallization, its dissolution, increase photostability. Oxidized CMC-g-PEG-DDA micelles reached values concentration, loading capacity encapsulation efficiency high 340 μg mL−1, 6.4 % 34.1 %, respectively. Loaded showed good stability limited release profile at pH 1.2, whereas 7.4 swollen cores enable much higher progressive release, reaches 3.4 6.6 after 3 5 h, respectively, corresponding very competitive concentration 34 66 mL−1.